MOTS-c

Axova Research MOTS-c is a high-purity laboratory reagent representing the unique mitochondrial open reading frame of the 12S rRNA type-c peptide. In biological and metabolic research models, MOTS-c is extensively investigated for its cellular autonomous signaling mechanisms that directly target metabolic homeostasis.

Unlike nuclear-encoded hormones, MOTS-c acts as an intracellular metabolic regulator. It is heavily utilized in laboratory studies to observe the activation of the AMP-activated protein kinase (AMPK) pathway, the upregulation of glucose transporter expressions (such as GLUT4), and the potential systemic reversals of diet-induced insulin resistance models.

Investigative Highlights:

• AMPK Pathway Activation: Researching cellular survival mechanisms, energy sensing, and nutrient-deprivation signaling cascades.
• Exercise-Mimetic Profiling: Investigating skeletal muscle glucose uptake and physical performance indicators in cellular models.
• Mitochondrial Homeostasis: Studying the cross-talk between mitochondrial and nuclear genomes during systemic metabolic stress.

Technical Specifications:

• Chemical Profile: Mitochondria-derived open reading frame of 12S rRNA peptide-c
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: 2174.62 g/mol
• CAS Number: 1627503-51-9
• Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Leu-Pro-Arg-Lys-Leu-Arg-NH2
• Purity: 99%+ (Verified by HPLC/MS)
• Physical State: Lyophilized white powder

Storage & Handling:

• Storage: Store desiccated at -20°C for optimal long-term stability. Post-reconstitution, store refrigerated at 2-8°C.
• Reconstitution: For precise analytical measurements and maximum peptide integrity, utilize Axova Research Bacteriostatic Water.

Shipping & Logistics:

• Orders are processed and dispatched within 1 business day.

Research Disclaimer:

• This product is strictly for Laboratory Research Use Only. Not for human or veterinary administration.