Axova Research TB-500 is a high-purity laboratory reagent representing the primary active domain of the endogenous mammalian protein Thymosin Beta-4. In biological, musculoskeletal, and soft-tissue injury models, TB-500 is heavily researched for its profound influence on cell proliferation and tissue remodeling cascades.
Unlike full-length proteins, the low molecular weight of this specific sequence allows it to diffuse easily across cellular structures. It operates primarily through the upregulation of actin—a vital protein component that forms the structural architecture of the cellular cytoskeleton. By binding to G-actin, researchers can study accelerated cell motility and migration, observing how specialized recovery cells navigate to localized areas of structural duress. Additionally, it is utilized in laboratory models to observe its synergistic relationship with native vascular endothelial growth factors to evaluate dual-pathway tissue remodeling in poorly vascularized systems.
| Actin Regulation & Motility | Researching the mechanical upregulation of actin to study the migration of fibroblasts and endothelial cells during structural tissue duress |
| Angiogenic Capillary Signaling | Investigating the formulation of new vascular networks to bypass damaged pathways and optimize systemic cellular response mechanisms. |
| Extracellular Matrix Deposition | Studying advanced collagen synthesis and cellular organization in complex tendon, joint, and ligament healing models. |
| Chemical Profile | Thymosin Beta-4 Active Fragment |
| Molecular Formula | C38H68N10O14 |
| Molecular Weight | 4963.44 g/mol |
| CAS Number | 885340-08-9 |
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr -Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly -Glu-Ser-OH |
| Purity | 99%+ |
| Physical State | Lyophilized white powder |
| Storage | Store desiccated at -20°C for optimal long-term stability. Post-reconstitution, store refrigerated at 2-8°C. |
| Reconstitution | For precise analytical measurements and maximum peptide integrity, utilize Axova Research Bacteriostatic Water. |
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