Axova Research SS-31 (also known as Elamipretide) is a high-purity, alternating aromatic-cationic peptide designed for direct inner mitochondrial membrane affinity. In cellular aging, neurodegenerative, and metabolic research models, SS-31 is highly investigated for its unique ability to cross biological barriers effortlessly and concentrate structurally independent of mitochondrial membrane potential.
The low molecular weight and distinctive structural architecture of this four-amino-acid sequence allow it to bind selectively to cardiolipin—a crucial lipid exclusive to the inner mitochondrial membrane. In laboratory settings, SS-31 is heavily studied for its capacity to prevent cardiolipin peroxidation, thereby optimizing the structural organization of the electron transport chain cristae. By stabilizing these microstructures, researchers utilize this compound to analyze the down-regulation of reactive oxygen species (ROS) production, the preservation of mitochondrial bioenergetics under chemical or ischemic duress, and the systematic recovery of baseline ATP synthesis profiles.
| Cardiolipin Structural Stabilization | Researching the targeted binding of cardiolipin to study the prevention of structural degradation in inner mitochondrial membranes. |
| Electron Transport Chain Optimization | Investigating the maximization of cellular ATP production efficiency and respiration mechanics within compromised cell models. |
| Mitochondrial ROS Mitigation | Studying the structural pathways responsible for lowering oxidative stress and neutralizing reactive oxygen species at their primary cellular source. |
| Chemical Profile | Mitochondria-Targeting Antioxidant Tetrapeptide |
| Molecular Formula | C32H49N9O5 |
| Molecular Weight | 639.80 g/mol |
| CAS Number | 736992-12-4 |
| Sequence | H-D-Arg-Tyr-Lys-Phe-NH2 |
| Purity | 99%+ (Verified by HPLC/MS) |
| Physical State | Lyophilized white powder |
| Storage | Store desiccated at -20°C for optimal long-term stability. Post-reconstitution, store refrigerated at 2-8°C. |
| Reconstitution | For precise analytical measurements and maximum peptide integrity, utilize Axova Research Bacteriostatic Water. |
Orders are processed and dispatched within 1 business day.
This product is strictly for Laboratory Research Use Only. Not for human or veterinary administration.
Axova Research supplies reference peptides to verified laboratories for research purposes only. Because you did not confirm you are 21 years of age or older and agree to our terms, access is not permitted.
